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Doctor's Best Phosphatidyl serine. SerinAid. Each softgel contains a 500mg Phospholipid Matrix, providing 100mg phosphatidylserine 45mg phosphatidylcholine, in a matrix of other cofactors that can enhance cell-to-cell communication. The incorporation of these molecules into membranes facilitates healthy cell function, toxin removal and cellular signaling. Phosphatidylserine, which makes up about 10% of the composition of neuronal cell membranes, may enhance healthy memory and thinking ability by facilitating neurol communication and may also support the body during times of stress. Even though we can make phosphatidylserine, some researchers believe that supplemental phosphatidylserine may be highly indicated as we age, since our natural diets may contain sub-optimal amounts of this nutrient. Some of the main indications for supplemental use of Phosphatidylserine include to support healthy brain activity and enhance cognitive function, support memory problems associated with aging and support the body during stressful times. 

This is what Doctor's Best have to tell us about Best Phosphatidylserine
Phosphatidylserine Provides Building Blocks for Healthy Neurons
Phospholipid molecules are key components of cellular membranes. The incorporation of these molecules into membranes facilitates healthy cell function, toxin removal and cellular signaling. One of the most important of these compounds for neural cells is phosphatidylserine (PS), which makes up about 10% of the composition of neuronal cell membranes.
Phosphatidylserine can be made by the body and is also taken into the body as part of the diet. Some researchers believe that supplemental PS may be highly indicated as we age, since our natural diets may contain suboptimal amounts of phosphatidylserine.
It is thought to be especially important in maintaining the general structure and function of the neuron. Supplemental phosphatidylserine may have beneficial effects on memory function by allowing neurons in the neuron networks to effectively communicate with one another.
Human Clinical Studies with Phosphatidylserine
A number of human clinical studies have been conducted using phosphatidylserine to support healthy brain activity. In a review of the effects of phosphatidylserine (PS) supplementation, the authors suggest that phosphatidylserine may be effective at enhancing cognitive function and supporting mild memory problems associated with aging based on the results seen in both animal and human studies.
One of the first double-blind controlled studies on PS was published in 1986, and consisted of 35 people with mild memory problems associated with aging taking either 100mg of animal derived PS three times per day or placebo.
The subjects were analyzed with tests designed to assess problems found in activities of daily life. They were tested after one week and six weeks of taking the supplement, and then three weeks after discontinuing. Although statistical significance was reached only in one test (The Peri Scale, a measure of mood, cognitive function, behavior and activities of daily living), the subjects taking the PS showed positive trends towards improvement on all three tests compared to the controls.
A double-blind, placebo-controlled study looked at 149 people supplementing with phosphatidylserine over 6 months. The subjects were given 200mg of PS or placebo orally for 3 months. Nine standard tests for brain function were used to analyze the subjects before and after the treatment, and then again at 6, 12, 18 and 24 months (after discontinuing the treatment).
They found that in the group most impacted by memory problems associated with aging there was a benefit of PS on a number of the cognitive tests performed, even up to 6 months after the discontinuation of the supplement.
Phosphatidylserine and age related memory loss
Phosphatidylserine was given to 494 elderly patients who had mild memory problems associated with aging. They were given 300 mg per day or placebo for six months. The individuals were examined at the beginning of the study, after three months of supplementation, and at six months.
Using a standardized scale to assess changes in behavior and cognitive function, they found statistically significant enhancement of cognitive function in the group who took phosphatidylserine. There didn't appear to be any side effects associated with the use of phosphatidylserine in this study.
A similar but shorter placebo-controlled study again looked at the effectiveness of phosphatidylserine in individuals with mild memory problems associated with aging. It involved 163 patients who again took 100 mg phosphatidylserine three times daily. They took the supplement for 12 weeks, and were evaluated every three weeks.
The benefits they found included enhancement of memory and name recall, learning, and ability to concentrate compared to the control group. The subjects tolerated the phosphatidylserine well and no side effects were reported.
Yet another trial, this one open-label (both the health provider and subjects were aware of the supplement given) looked at phosphatidylserine derived from plant sources on 15 people with mild memory problems associated with aging. The study lasted for 12 weeks, and the participants were evaluated by standard memory and learning tests 3 times (at baseline, 6 weeks, and 12 weeks).
They were all given 100mg of PS, in PS enriched lecithin Capsules, three times per day. They found that the subjects performed significantly better on most of the tests after supplementing with PS compared to before supplementation, and 9 subjects reported improvement of their memory in day to day tasks. Although this study was open-label, the results fit in well with previous studies using phosphatidylserine.
Phosphatidylserine Supports the Body During Mental Physical Stress
A number of small studies have emerged that have shown positive effects of PS supplementation on the stress response. The majority of the studies have looked at the effects on stress induced from physical exertion, although one study in 2001 looked at the effects on mental stress in 48 male university students. These students were given either 300mg of PS or placebo for 30 days.

Baseline and post-supplementation measurements of mood, neuroticism and extroversion were assessed by questionnaire, and vital signs were taken. After 30 days, the students were given a standard acute stress test involving a difficult time-limited mathematical calculation, and then measurements were taken a third time. The sub-group of students who were rated more neurotic experienced significantly less stress and better mood under the pressure by taking PS compared to placebo.
A further crossover study of 8 healthy men looked at the effects of an acute dose of PS on hormonal responses after physical stress. The men underwent physical exercise between 8:30 and 9:30am after an overnight fast. They were each tested 3 times in a crossover fashion with a one-week interval between testing. Blood samples were taken before exercise, and were followed by an intravenous injection of either placebo, 50 mg of PS, or 75 mg of PS. Subsequent blood samples were taken during and after exercise.
The secretion of both cortisol and ACTH (the pituitary hormone that regulates cortisol) were significantly blunted after exercise by supplementation with phosphatidylserine, as compared to placebo. Other hormones, including norepinephrine, epinephrine, growth hormone, and dopamine were not affected by phosphatidylserine supplementation.
The author showed a similar significant response of oral PS on cortisol and ACTH after exercise stress in 9 healthy men. Subjects took 800 mg of phosphatidylserine or placebo orally for 10 days in a double-blind, randomized cross-over study.
In another investigation, eleven fit male subjects with at least 4 years of weight training experience were given 800mg of phosphatidylserine or placebo for two weeks in a cross-over study. During this time they were involved in eight intensive weight lifting sessions over the two weeks. Although resting cortisol levels did not differ throughout the training in the phosphatidylserine versus the placebo groups, the post-exercise level of cortisol was significantly lower in the PS group. ACTH was not affected by phosphatidylserine supplementation in this study.
The PS significantly enhanced the perception of well-being and lowered ratings of muscle soreness in response to the severe over-training they underwent during the study. The severity of the training was confirmed by increases in creatine kinase (a measure of damage to the muscles) in both groups.


Doctor's Best Phosphatidylserine:

Provides building blocks for healthy neurons
Supports healthy memory and thinking ability
Supports healthy brain activity
Helps with age related memory problems
Enhancement of cognitive function
Support the body during mental and physical stress


Each 1 softgel contains: SerinAid Phosphatidylserine 500mg providing: Phosphatidylserine (PS) 100mg, phosphatidylcholine 45mg, Medium chain triglycerides 150mg. Other ingredients: Softgel Capsule (gelatin, glycerin, purified water), Soybean oil. Contains Soy. Not suitable for vegetarians.


Adults: Take one softgel 2 or 3 times a day with meals, or as recommended by your physician.
In the brochure Phosphatidylserine, Vital Lipid for memory, mood and stress, by Parris M Kidd Ph.D it talks about:
How to take PS for best results.
"A good way to get going on PS is to pre-load at 200-300mg per day for the first month. This is the dosage range used in the trials. Most people experience benefit at this level within three weeks to three months. Some adults and children, will take longer to experience benefits. Once improvement kicks in, the higher intake can be continued for further benefit, or reduced to as low as 100mg per day."


Keep out of reach of Children.