Hormone Balance - DIM
Radiance Hormone Balance - DIM. Diindolylmethane. Healthy Oestrogen Metabolism. Radiance DIM provides the enhanced delivery system and scientific validation of premium quality BioResponse DIM, a unique formulation containing bio-available diindolylmethane, a compound found in cruciferous vegetables such as broccoli. BioResponse DIM has been shown to support normal, healthy oestrogen metabolism and healthy oestrogen metabolite ratios a function important in both men and women particularly for the health of breast, uterus, prostate and other reproductive tissue. With 18.5mg of bioavailable diindolylmethane per veggie cap.
What is Diindolylmethane or DIM?
Diindolylmethane (DIM) is the most active cruciferous substance for promoting beneficial estrogen metabolism in women and men. DIM is found in cruciferous vegetables including broccoli, cauliflower, cabbage and Brussels sprouts. It is formed from its precursor indole, Indole-3-carbinol (I3C), after the enzymatic release of I3C from parent glucosinolates found in all cruciferous vegetables.
The supplemental use of DIM began with early experiments which demonstrated that animal diets with added DIM, like diets with added cruciferous vegetables, prevented chemically induced cancer.
Pure DIM was first used in 1987 as a dietary supplement in animals, shown to be non-toxic, and to prevent breast cancer caused by the carcinogen, dimethylbenz(a)anthracene. Similarly, the initiation pathway to chemically induced colon cancer was inhibited with the DIM precursor, I3C.
The mechanisms by which DIM prevents cancer in animals has subsequently been shown to involve a reduction in activity of the estrogen receptor system, promotion of beneficial estrogen metabolism, and support for selective apoptosis, or "programmed cell death" which removes damaged cells.
Supplemental use of DIM in humans is effective in adjusting the pathways of estrogen metabolism to favour the production of 2-hydroxy estrogen metabolites. These shifts in estrogen metabolites were significant and showed an approximate 75% increase in production of 2-hydroxyestrone and a 50% decrease in 16-hydroxyestrone . An increased proportion of 2-hydroxy metabolites is correlated to protection from breast cancer. This relationship has been documented in several case-control studies.
What have the studies shown?
Case-control studies have also documented that low levels of 2-hydroxy metabolites are associated with breast cancer in women, breast cancer in men, familial risk of breast cancer, uterine cancer, cervical cancer, and systemic lupus erythematosis. An increase in the rate of breast cancer has now been associated with lupus. Many established risk factors for breast cancer including obesity, high fat diets, and diets deficient in Omega 3 fatty acids have also been correlated with low 2-hydroxy estrone production.
DIM is unique among all phytonutritionals with regard to its ability to favourably modify estrogen metabolism in the direction of greater 2-hydroxy estrogen production. Unlike soy isoflavones, genistein and daidzein, DIM is not an estrogen mimic or "phytoestrogen" and has no inherent estrogenic activity. DIM acts to balance the natural response to estrogen by adjusting the activity of metabolic cytochrome enzymes and specialized estrogen receptor molecules.
Usage of Hormone Balance - DIM is indicated for both men and women, especially those with a predisposition to hormone reactive cancers such as breast or prostate cancer. Also women with premenstrual tension. Menstrual or menopausal problems. Promotes fat loss. Supports healthy breast, cervical, uterine and prostate tissues. Increase the level of "good" oestrogens (2-hydroxyoestrogen) while reducing the level of "bad" oestrogens (16-hydroxyoestrogen)
Each Capsule contains: Bio-Response DIM complex 75mg, (Providing 18.5mg bioavailable diindolylmethane) 100% vegetarian. Cellulose Capsule, corn starch, natural vitamin E, phosphatidylcholine (soy), silica. NO gluten, dairy, artificial preservatives, flavourings or colours.
Radiance Hormone Balance - DIM contains BioResponse DIM, which is a registered trademark of Nutrients LLC, USA.
Women: Two to four Capsules daily with food
Men: Two to four Capsules twice daily with food
Keep out of reach of children. Not to be used in pregnancy or lactation. A harmless but noticeable change in urine colour (pink) may occur during usage. Caution with certain medications including thyroid hormone therapy. Close lid tightly. Store in a cool dry place.