Coromega Omega 3 Squeeze. Contains premium quality fish oil from deep, cold water fish. Coromega uses the natural triglyceride form of fish oil, molecularly distilled and third party tested for purity. Each 2.5gram packet contains delicious orange flavoured fish oil, in a convenient tasty liquid, with 2000mg of fish oil, 650mg long chain fatty acids, 350mg EPA and 230mg DHA. Eye, brain function, cardiovascular health. Coromega is tasty and convenient taken directly from the pouch, but it can also be introduced to your diet in many cool and creative ways and this will not alter the effectiveness. Mix with yogurt, blend in a smoothie, or squeeze on top of fruit or even ice cream. (Because Coromega is emulsified, it should not be heated or frozen because it will cause the emulsion to separate) It will not stir into liquids, but can be put with liquid in a blender and wizzed together. Contains egg. 90 squeeze packets

Bioavailabilty Study of Coromega
Enhanced Absorption of Omega -3 Fatty Acids from Emulsified Compared with EnCapsulesulated Fish Oil
Susan. K. Raatz, PhD, RD J. Bruce Redmon, MD Nyra J. Wimmergren, RN James V. Donadio, MD* Douglas M. Bibus, PhD.

General Clinical Research Center and Department of Medicine, University of Minnesota, Minneapolis, MN, *The Mayo Clinic, Rochester, MN

J Am Diet Assoc. 2009 109:1076-1081

ABSTRACT

The omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have properties important in nutrition and disease management. Presently fish oil (FO) supplementation relies on Capsulesular triglyceride, but novel delivery systems are emerging. Flavored emulsified lipid preparations provide a simplified approach to fish oil delivery. Oil in water emulsions are hypothesized to possess advantages in the digestion and absorption of their fatty acids thus increasing the bioavailability of the active components. A randomized, crossover designed study compared absorption kinetics of EPA and DHA in 10 subjects consuming 5g (4g of fish oil) of an emulsified fish oil (Coromega) or the equivalent of the parent oil (4g of fish oil) in Capsulesular form. Blood was obtained at 0, 2, 4, 8, 24 and 48 hours and a tolerance questionnaire was completed at 4 hours post ingestion. Peak absorption at 8 hours was assessed. Emulsified fish oil promoted increased bioavailability of omega-3 fatty acids with enhanced area under the curve (AUC) through 8 hours. The AUC (% FFA x min) was statistically significant for total omega-3 fatty acids (emulsified FO vs. parent FO, respectively) 1102 &plusmn 23, 319 &plusmn 13 (p = 0.012), EPA 771 &plusmn 161, 314 &plusmn 82 (p = 0.001), and trended toward significance for DHA 393 &plusmn 29, 70 &plusmn 16 (p = 0.18). Subjects reported no tolerance problems with the emulsified lipid preparation compared to mild reports of fishy burp with the Capsulesular triglyceride. Oil in water emulsions are a highly bioavailable, highly tolerable method of delivery for long chain omega-3 fatty acids from fish oil.

BACKGROUND

The omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have properties important in nutrition and disease management.

Presently fish oil supplementation relies on Capsulesular triglyceride but novel delivery systems are emerging.

Flavored emulsified lipid preparations provide a simplified approach to fish oil delivery.

Oil in water emulsions are hypothesized to possess advantages in the digestion and absorption of their fatty acids thus increasing the bioavailability of the active components.

HYPOTHESIS AND SPECIFIC AIMS

Hypothesis: Emulsified triglyceride will be absorbed faster and to a greater extent compared to a similar dose of the parent triglyceride based on its pre-emulsified state.

Specific Aims:

To evaluate the effects of feeding a single dose, 4g fish oil (5g Coromega), of emulsified lipid containing EPA and DHA from fish oil on plasma fatty acids over a 48 hour period.
To evaluate the extent and rate of absorption of EPA and DHA in healthy subjects fed equivalent doses of fish oil from either a emulsified triglyceride versus a enCapsulesulated triglyceride of similar EPA and DHA dosages.

STUDY DESIGN

A randomized and crossover design with 10 subjects

Healthy adults ages 18 to 60
Body mass index between 22 and 32 kg/m2
Medical history demonstrating good health
Nonsmokers
Consumption of a typical American diet with no unusual dietary habits
Willingness to comply with the study protocol

Treatments

Active: 5 g (4 g of fish oil) of Coromega
Placebo: 4 g of parent oil

Assessment of absorption kinetics of EPA and DHA

Plasma obtained at baseline, 2, 4, 8, 24 and 48 hours
Peak absorption at 8 hours was assessed in total phospholipid

SUMMARY AND CONCLUSIONS

Summary
Emulsified FO promoted increased bioavailability of omega-3 fatty acids with enhanced area under the curve (AUC) through 8 hours.

The AUC (% FFA x min) was statistically significant for Total omega-3 fatty acids (emulsified FO vs. parent FO, respectively) 1102 &plusmn 23, 319 &plusmn 13 (p = 0.012), EPA 771 &plusmn 161, 314 &plusmn 82 (p = 0.001).

DHA trended toward significance for 393 &plusmn 29, 70 &plusmn 16 (p = 0.18).

Subjects reported no tolerance problems with the emulsified lipid preparation compared to mild reports of fishy burp with the Capsulesular triglyceride.

Conclusions
Oil in water emulsions are a highly bioavailable, highly tolerable method of delivery for long chain omega-3 fatty acids from fish oil.

Some Of The Specific Health Benefits of Omega 3
Heart Health Many extensive medical studies show that Omega-3 fish oils are good for overall heart and cardiovascular health. Omega-3 also supports healthy triglyceride levels and is recommended by both The American Heart Association and The National Institutes of Health (NIH). CoQ10 has also been shown to support heart health.

Brain Health DHA, one of the critical fatty acids in Omega-3, is the essential building block of the brain. DHA comprises over 30% of the fatty acids found in the brain and plays a vital role in how our cells function. Higher levels of DHA have been shown to support healthy brain development. Also, research in the last few years has revealed that diets rich in Omega-3 support a healthy emotional balance and positive mood, and may help to maintain a healthy mental status in later years.

Prenatal and Children Health Omega-3, especially DHA, is crucial for the healthy development of babies and children's brain and eyes. 98% of baby formulas are now fortified with DHA. Omega-3 DHA helps to support children overall growth and development.

Joint Health Mobility Omega-3 fatty acids may block some of the body's processes that limit joint health and freedom of movement and have been found to help with joint stiffness and associated discomfort. More than a dozen studies in the last 10 years have found that a diet with a more balanced intake of Omega-3 to Omega-6 fatty acids may help maintain healthy joints.

Fish Oil (wild caught anchovies and sardines), Water, Pasteurized Egg Yolk, Natural Orange Flavor, Ascorbic Acid, Sodium Ascorbate, Stevia Leaf Extract, Vegetable Oil, D-alpha Tocopherol, Citric Acid, Potassium Sorbate, Sodium Benzoate, Vanillin, Beta Carotene Color, Xanthan Gum, Menthol.

Delicious orange flavour. No sugar or artificial sweeteners. NO dairy, yeast, wheat or gluten. Store in a cool, dry place. Avoid exposure to heat. Do not freeze or heat. Coloured with beta carotene. No sugar or artificial sweeteners. Contains egg.

Adults and children over 4 years of age. Take one packet daily with or without food, or as directed by your health professional.

Tear or cut along the perforation and squeeze directly in your mouth or onto a spoon. Coromega can be added to cold food, such as yoghurt or mixed with a beverage (electric blending required) While Coromega does not require refrigeration, some people prefer to take it cold (Do not freeze or heat). Each 1 packet provides 350mg of EPA and 230mg of DHA. 0 carbohydrates as it is sweetened with stevia.

Keep out of reach of Children. Allergy warning. Contains egg.