Doctor's Best SAMe, featuring 200mg of S-Adenosyl Methionine, from 400mg of SAM-e tosylate disulfate. Benefits of taking SAMe include enhances mood and neural function, promotes joint comfort and mobility and supports liver health and detoxification. SAMe is a nutrient unequaled for its health benefits. Doctor's Best SAMe is optimized for potency, stability and to survive the stomach acid and reach the intestine, where it is absorbed. SAMe's remarkable benefits come from its very high energy content, coupled with its unique molecular structure, facilitating its use as an enzyme cofactor. Literally thousands of enzymes in the body use the energy build into SAMe to overcome energy barriers and thereby to power key metabolic pathways. This Italian made SAMe is processed to yield the highest percentage of the "active" pure S,S form of SAMe on the market Pharmaceutical grade. Made in Italy. Suitable for vegetarians. 60 Enteric coated tablet. Sealed in blister packs for freshness and convenience.
Some of the reported benefits of taking SAMe
SAMe - Potent promoter of mood and cognitive health
SAMe is essential for the healthy metabolism of the major brain transmitters dopamine, serotonin and norepinephrine. SAMe is also essential for the main metabolic pathways that makes phosphatydlcholine (PC), a key cell membrane phospholipid for the nerve cell information connections (synapses)
Myellination - insulation of the nerve cell extensions to optimize their electrical conduction, also requires SAMe.
SAMe is also essential for the brain to produce melatonin, a hormone that regulates healthy sleep patterns.
Those with mood difficulties, often also have problems with memory and other cognitive functions. In a 2010, double blind trial, SAMe supported cognitive health while promoting healthy mood. SAMe supports the metabolism of acetylcholine, a major nerve transmitter that is essential for learning, attention and memory and for numerous other functions outside the brain.
Even as SAMe ameliorates mood difficulties, SAMe also has improved energy levels, as found in two other double-blind trials.
Optimal SAMe intakes for mood and cognitive support are 800-1600mg per day, preferably as divided doses taken between meals.
SAMe - Promotes Joint comfort and mobility
Clinical trials using SAMe for joint problems, conclude that SAMe is a "premier joint support nutrient". Even at high doses, SAMe was very well tolerated and researchers conducting these trials noted SAMe's relative lack of adverse effects and its capacity to continue improving joint comfort and mobility over the entire period of the trial.
The tissues of the working joint have a matrix of collagen and proteoglycans, large fiberous molecular complexes that give the joint structural stability. SAMe's energized "active sulfur" group supports collagen and proteoglycan formation. SAMe's active sulfur also supports the bio-synthesis of glutathione, cysteine and taurine, key components of the joints antioxidant defenses, as well as that of the liver and the body as a whole.
SAMe Protects and supports the liver and intestines
The liver makes most of the body's SAMe and itself, relies heavily on SAMe for its structural and functional integrity. The livers SAMe reserves are readily depleted by alcohol consumption or by a variety of chemical toxins.
In three human trials, supplementation with SAMe protected the liver against alcohol or other man made toxins. These benefits of SAMe are most likely mediated by its support for the liver pathways that make glutathione and the other sulfur antioxidants.
Most of the livers glutathione comes ultimately from SAMe. The liver is the major organ wherein "active sulfur" from SAMe is fed into the vast web of sulfur pathways that make glutathione and the other sulfur antioxidants. These are at the hub of the livers considerable detoxification activity and also provide its major defense against chemical damage.
Functionally, glutathione status (and therefore liver health) is highly dependent on SAMe experimental depletion of glutathione causes SAMe to be used up in replacing the glutathione, while repleting SAMe leads to restoration of glutathione reserves.
In addition to its multifaceted support in liver detoxification, SAMe also supports the liver's bile secretion function, as reported in at least two clinical trials.
SAMe also helps keep the colon healthy. The colon normally houses bacteria that produce hydrogen sulfide, which is potentially toxic to biomolecules. The cells that line the colon use SAMe to detoxify hydrogen sulfide. In a clinical study, difficulties with colon function were linked to low blood levels of SAMe.
These are just a few of the many clinicial trials done to discover the health benefits of SAMe.
Doctor's Best SAMe:
Potent promoter of mood and cognitive health
Promotes joint comfort and mobility
Protects and supports the liver and intestine
Methyl source for genetic, epigenetic and other vital processes
Vital for the production of melatonin, a hormone that regulates healthy sleep patterns
Each enteric coated tablet contains: S-Adenosyl Methionine 200 mg, (from 400 mg of SAM-e tosylate disulfate). Other Ingredients: Cellulose gel, methacrylic acid copolymer, comprtol 888ATO, talc, triethyl citrate, titanium dioxide, magnesium stearate, mannitol, glycerol palmitostearate, silica, medium chain triglycerides, sodium starch glycolate and iron oxide. Suitable for vegetarians.
Adults: Take 1 tablet daily away from food, or as directed by a health care professional.
Do not chew or crush tablet. Swallow whole.
Keep out of reach of Children. Warning: Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.
Orders within New Zealand are dispatched by courier once your payment has been processed. Our customer service team aim to dispatch your order within 24 hours during the working week. Within Auckland please allow 48 hours for delivery. For all other areas please allow 72 hours.
Within NZ, supplement orders over NZ$70 are conveniently delivered freight free. Freight Free may exclude food items and cleaning products - we will contact you if additional courier charges apply to your order containing these items. Orders under NZ$70 in value will have a delivery charge based on the delivery address.
• Auckland (Wellsford to Pukekohe) - $5.00
• Rest of the North Island - $6.50
• South Island - $8.00
Auckland orders have the option to be collect, free of charge. We are located at 344a Rosedale Road, Albany, Auckland 0632. Please note that collection is only available between 10am and 4pm, Monday to Friday.
International orders are sent out using tracked international services. Delivery for international orders usually take 5-10 business days to arrive. Freight charges for international orders are based on the weight of the total order.