Doctor's Best Stabilized R-Lipoic Acid, featuring BioEnhanced Na-RALA, the sodium salt of R-Lipoic acid (RLA). R-Lipoic Acid defends against free radicals, recycles the antioxidant Vitamins C E in the body, helps maintain healthy glucose metabolism, supports cognitive function and brain health, as well as eye health, cardiovascular health and support in healthy aging. Pure RLA is a very unstable molecule that has a tendency to polymerize with exposure to heat, light and moisture. BioEnhanced Na-RLA is a stabilized form of lipoic RLA that wont degrade at high temperatures. By taking the sodium salt of RLA, its solubility is increased and it has an improved dissolution in the body. It is more bioavailable than regular RLA and has no solvent residues. D-Biotin has also been added, as the need for this vitamin increases with lipoic acid supplementation. 100mg per veggies Capsule. Suitable for vegetarians. 60 Veggie Capsules
This is what Doctor's Best has to tell us about Best Stabilized R-Lipoic Acid
R-Lipoic Acid Supports the body's defense against free radicals. ALA recycles antioxidant nutrients such as Vitamin C and Vitamin E
An ideal antioxidant would have the ability to quench a wide variety of free radicals, to support the functioning of other antioxidants, to bind or chelate metal ions that can generate free radicals, to function in watery and fatty environments, and to be present in tissues, cells, and extracellular spaces. Having exceeded these criteria, Lipoic Acid was termed the universal antioxidant."
As a team, LA and DHLA come close to the ideal, for the following reasons:
1) LA is easily absorbed when consumed orally.
2) LA is readily converted to DHLA in various tissues.
3) As a pair, LA and DHLA neutralize superoxide, hydroxyl, peroxyl, and hypochlorus radicals.
4) LA and DHLA form stable complexes with metal ions such as iron, manganese, copper and zinc ions.
5) LA and DHLA scavenge free radicals in both fatty and watery environments.
6) DHLA recycles other important antioxidants.
Within the cell, antioxidants work as a team to keep free radicals from damaging cell structures. In order to neutralize a free radical, an antioxidant such as vitamin C must give up an electron, which means it becomes oxidized. Before it can function as an antioxidant once again, it must be regenerated back to its "reduced" form by gaining an electron to replace the donated electron. For this, it needs the help of other antioxidants. Vitamin C, vitamin E, and glutathione are key antioxidants that can be generated by cycling between their oxidized and reduced forms. This is necessary to maintain the balance between oxidation and its reverse--the neutralization of free radicals by antioxidants.
DHLA is an essential component in the interaction between these antioxidants, as well as being able to recycle coenzyme Q (CoQ). Studies show that addition of alpha-lipoic acid to liver tissues results in increased vitamin C levels. It has been found that DHLA is responsible for regenerating vitamin C, which in turn regenerates vitamin E. DHLA also converts glutathione from its oxidized form back into its free radical scavenging reduced form.The LA/DHLA pair is thus vital for answering "oxidative stress," which occurs when the balance is tipped in favor of oxidation in cells. DHLA helps preserve antioxidants in both the watery cell interior and the fatty structure of cell membranes. Evidence from animal studies suggests the free radical-scavenging activity of DHLA in the mammalian brain.
Alpha-lipoic acid helps maintain healthy glucose metabolism
Alpha-lipoic acid is a key factor in the cellular process that metabolizes glucose for energy production. Researchers have noted that for a non-hormonal compound, LA is remarkable for its effect on carbohydrate metabolism&mdashespecially the R-lipoic form of alpha-lipoic acid. For example, in vitro studies have shown the ability of RLA to promote rapid uptake of glucose in muscle and fat cells. The impact of lipoic acid administration in promoting healthy blood sugar metabolism is also evidenced in numerous animal and human studies.
After helping to initially increase glucose uptake into cells, RLA subsequently increases glucose utilization via activation of an enzyme complex&mdashcalled the pyruvate dehydrogenase complex&mdashinvolved in energy production inside the mitochondria of cells. LA is cited especially for its ability to reduce oxidative stress in the context of the important relationship between healthy blood sugar levels and vascular health.
Alpha lipoic acid supports healthy aging
As we age, our ability to synthesize lipoic acid decreases. Age also brings an accumulation of oxidized proteins that interfere with mitochondrial efficiency. LA's status as a so-called mitochondrial nutrient addresses this situation. Furthermore, aging is accompanied by a decreased ability of the liver to recycle ascorbic acid following oxidative stress. R-lipoic acid, after two weeks of supplementation to aged rats, reversed the age-related impairment of ascorbic acid recycling and concentration in liver cells.
Alpha-lipoic acid supports cognitive function and brain health
Aging is associated with oxidative stress in the brain. The brain's high rate of metabolism and its long-lived neurons make it particularly vulnerable to oxidative stress. Since LA interrupts cellular oxidative processes in both its oxidized and reduced forms, it plays a modulatory role in the brain and nervous system.
Preliminary research on humans suggests that LA supports sustained cognitive function in older age.
Alpha lipoic acid supports eye health
Studies also indicate that supplementation with alpha-lipoic acid supports eye health. One of the most toxic chemicals in cigarette smoke, acrolein, is especially harmful to retinal pigment epithelial cells. Rats chronically exposed to low doses of acrolein lose the viability of these cells, showing a decrease in mitochondrial function due to oxidative stress. Pretreatment of these retina cells with LA before the acrolein exposure significantly protected them from oxidative damage. RLA is exceptionally suitable for supporting the retina of the eye.
Alpha lipoic acid supports cardiovascular health
Alpha-lipoic acid may offer several different mechanisms in helping us to maintain cardiovascular health. From animal studies, researchers began to discover the impact of LA on blood lipids over half a century ago. Additionally, a recent study in mice demonstrated results seen in previous studies using mice or rats: lipoic acid lowered body weight gain and fat mass. Researchers attributed this to appetite suppression and enhanced energy expenditure. Mice in this same study also benefited from lower levels of triglycerides upon LA administration.
While the favorable results seen in many of these in vivo studies have not yet been investigated in humans, researchers believe that LA supplementation holds promise for supporting the cardiovascular system through such means as helping to maintain a healthy weight and by promoting healthy lipid metabolism.
Stabilized R-Lipoic Acid vs. Controlled Release Products
Some companies are marketing controlled release or sustained release alpha-lipoic acid products, which maintain plasma concentrations for a longer period of time. However, available research adequately demonstrating the superiority of such products is lacking. Marketers of controlled release products claim that the therapeutic effectiveness of other lipoic acid products is limited due to the fact that it reaches peak concentrations in the bloodstream very quickly and therapeutic concentrations are not maintained. However, this is a misrepresentation of the large body of research indicating this is a fundamental beneficial property of lipoic acid, not a shortcoming.
Current scientific research into lipoic acid's mechanisms inside the body, rather than in the Petri dish, suggest that the rapid plasma clearance is fundamentally related to its safety and therapeutic action. Reaching an effective concentration is critical to the therapeutic action of lipoic acid, and rapid uptake and clearance from the bloodstream is a beneficial attribute rather than a shortcoming. Recent evidence indicates that inside the body, the antioxidant effect of lipoic acid is due to its ability to modulate gene expression and cell signaling molecules and to stimulate glutathione synthesis.
Doctor's Best Stabilized R-Lipoic Acid:
Defends against free radicals
Recycles the antioxidant Vitamins C E
Helps maintain healthy glucose metabolism
Supports health aging
Supports cognitive function and brain health
Supports eye health
Supports cardiovascular health
Each 1 veggie Capsule contains: D-Biotin150 mcg, R-Lipoic acid 100 mg (from 125 mg Sodium R-alpha Lipoate (BioEnhanced NA-RALA)). Other Ingredients: Modified cellulose (vegetarian Capsule), rice powder, microcrystalline cellulose, magnesium stearate (vegetable source), silicon dioxide. Contains nothing other than listed ingredients. Does Not Contain: milk, egg, wheat, gluten, corn, soy, sugar, sweeteners, starch, or preservatives.
Suggested Adult Use: Take 1 - 2 Capsules daily, or as directed by a nutritionally informed physician.
Keep out of reach of Children.
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