NOW Foods Liver Refresh is a comprehensive multi-ingredient liver support formula that combines Milk Thistle Extract standardised to 240mg of Silymarin Flavonoids with L-Glutathione, Alpha Lipoic Acid, Grape Seed Extract, L-Carnitine, Schisandra, Baikal Skullcap, Barberry, and organic Turmeric - alongside an Artichoke, Beet, and Raspberry Leaf herbal blend.
Designed to support the liver’s role in the body’s natural detoxification processes and promote healthy liver function, this is a broader formula than a standalone Milk Thistle supplement, combining the most researched liver herb with a complementary stack of antioxidants, botanicals, and amino acids.
Vegan, gluten-free, and free from dairy, soy, eggs, nuts, and shellfish. Made and quality tested in the USA with globally sourced ingredients.
- Milk Thistle Extract standardised to 240mg Silymarin Flavonoids - the active polyphenol complex of Milk Thistle (Silybum marianum) at a meaningful dose; Silymarin is the most researched compound for liver health, with a well-established role in supporting liver cell protection, regeneration, and normal liver function
- L-Glutathione (Reduced) 200mg - glutathione is often called the body’s master antioxidant and is found in high concentrations in the liver, where it plays a central role in Phase II detoxification pathways and the neutralisation of free radicals and reactive compounds; reduced L-Glutathione is the biologically active form
- Alpha Lipoic Acid 100mg - a potent, fat and water-soluble antioxidant that supports the liver’s own antioxidant network, including the regeneration of glutathione; particularly relevant for liver health due to its ability to function in both aqueous and lipid environments within liver cells
- Grape Seed Extract 100mg (standardised for Polyphenols) - a concentrated source of oligomeric proanthocyanidins (OPCs) and other polyphenols with potent antioxidant and anti-inflammatory activity, contributing to cellular protection alongside the other antioxidants in the formula
- Schisandra (Fruit) 100mg - a traditional Chinese medicine adaptogen and hepatoprotective herb, widely used for centuries to support liver health and resilience; associated with supporting Phase I and Phase II liver enzyme activity and protecting liver cells from oxidative stress
- L-Carnitine 50mg - an amino acid that plays a role in fatty acid transport and energy metabolism within liver cells, relevant for supporting healthy liver lipid handling
- Artichoke, Beet, and Raspberry Leaf Herbal Blend 90mg - Artichoke Leaf is a traditional liver and gallbladder support herb; Beet Root is associated with liver fat metabolism and antioxidant activity; Raspberry Leaf provides additional phytonutrient support
- Baikal Skullcap (Root) 50mg - a traditional Chinese herb (Scutellaria baicalensis) with well-documented anti-inflammatory and antioxidant properties, widely used in liver-focused herbal formulas
- Barberry (Root Bark) 30mg and Organic Turmeric (Root) 30mg - Barberry provides berberine and other alkaloids with liver-supportive and antimicrobial properties; Turmeric contributes curcumin’s anti-inflammatory and antioxidant activity
- L-Methionine 20mg - a sulphur-containing amino acid that plays a role in liver detoxification pathways and the synthesis of other key compounds including glutathione
- Vegan, halal, gluten-free, and free from dairy, soy, eggs, nuts, and shellfish; made in a GMP-certified facility
Take 3 capsules daily with food.
Per 3 capsules:
Milk Thistle Extract (Silybum marianum) (Fruit/Seeds) (Standardised to 240mg Silymarin Flavonoids - Equivalent 80%) - 300mg
Herbal-Enzyme Blend - 90mg: Artichoke (Cynara scolymus) (Leaf), Beet (Beta vulgaris) (Root), Raspberry (Rubus idaeus) (Leaf), Pancreatin (Pancreatic Enzymes)
L-Glutathione (Reduced) (Setria™) 200 mg
Grape Seed (Standardized Extract)
(Vitis vinifera) (Standardized for Polyphenols) 100 mg
Alpha Lipoic Acid 100 mg
L-Carnitine (from L-Carnitine Tartrate) 50 mg
Scute (Root) (Scutellaria baicalensis) 50 mg
Schisandra (Fruit) (Schisandra chinensis) 100 mg
Barberry (Root Bark) (Berberis vulgaris) 30 mg
Organic Turmeric (Root) (Curcuma longa) 30 mg
L-Methionine 20 mg
Other ingredients: Microcrystalline Cellulose, Hypromellose (cellulose capsule), Gum Arabic, Ascorbyl Palmitate, Stearic Acid (vegetable source), Silicon Dioxide, Maltodextrin (non-GMO).
For adults only. Consult a healthcare professional if pregnant or nursing, taking medication, or if you have a medical condition. Consult a healthcare professional if you have an allergy to plants of the Asteraceae family. Keep out of reach of children. Natural colour variation may occur in this product.
NOW Foods Liver Refresh takes a considerably broader approach to liver support than a standalone Milk Thistle supplement. Rather than relying on a single botanical, the formula combines Milk Thistle - the most well-researched liver herb available - with a supporting cast of antioxidants, amino acids, and botanicals that address liver health from multiple angles simultaneously.
Milk Thistle Extract, standardised to provide 240mg of Silymarin Flavonoids per serving from 300mg of extract, forms the foundation. Silymarin is the collective name for the polyphenolic compounds extracted from Milk Thistle seed, and is one of the most extensively studied natural compounds in hepatology. Research has explored its role in protecting liver cells from oxidative damage, supporting liver cell regeneration, and maintaining normal liver enzyme levels.
L-Glutathione at 200mg per serving adds one of the liver’s most important endogenous antioxidants in direct supplemental form. The liver is the body’s primary site of glutathione synthesis and concentration, using it continuously in Phase II detoxification pathways to neutralise and facilitate the elimination of reactive compounds, heavy metals, and environmental toxins. Alpha Lipoic Acid at 100mg complements this by supporting the regeneration of glutathione and other antioxidants in both the fat-soluble and water-soluble environments within liver cells - an unusual capability that makes it particularly useful in a liver support context.
The botanical component of the formula is equally considered. Schisandra has centuries of use in Traditional Chinese Medicine for liver health and hepatoprotection, with modern research exploring its effects on liver enzyme activity and oxidative stress. Baikal Skullcap and Barberry are traditional anti-inflammatory and antimicrobial herbs with strong phytochemical profiles. Artichoke Leaf is a well-established choleretic herb used to support bile production and liver and gallbladder function. The L-Carnitine and L-Methionine amino acids round out the formula with support for the metabolic functions of the liver, including fatty acid transport and the synthesis of key sulphur-containing compounds. Available in 90 and 180 veg capsule packs at 3 capsules per day.
Why choose a combination liver formula over a standalone Milk Thistle supplement?
A standalone Milk Thistle supplement provides Silymarin at a concentrated dose, which is well-evidenced for liver cell protection and regeneration. A combination formula like Liver Refresh addresses liver health from multiple angles simultaneously - antioxidant defence (Glutathione, Alpha Lipoic Acid, Grape Seed Extract), botanical hepatoprotection (Milk Thistle, Schisandra, Baikal Skullcap), detoxification pathway support (Glutathione, L-Methionine), and metabolic liver function support (L-Carnitine). Those wanting targeted, high-dose Milk Thistle alone may prefer a standalone product; those wanting broader liver and detox support in a single formula are better served by Liver Refresh.
What is Silymarin and why is it standardised?
Silymarin is the collective name for the bioactive polyphenolic flavonolignan compounds in Milk Thistle, including Silybin, Silydianin, and Silychristin. Standardising to 80% Silymarin Flavonoids means 80% of the extract’s weight is these active compounds - in this case delivering 240mg of Silymarin from 300mg of extract. Standardisation ensures consistent, predictable potency across every batch.
Why is glutathione included as a supplement when the body makes its own?
The liver naturally produces and concentrates glutathione and uses it continuously in detoxification and antioxidant processes. However, glutathione levels can be depleted by heavy detox loads, alcohol, pollution, medications, illness, and ageing. Supplementing with reduced L-Glutathione - the biologically active form - supports the body’s supply of this critical compound. Alpha Lipoic Acid in this formula also supports the regeneration of glutathione, providing a two-pronged approach.
What does Schisandra do for the liver?
Schisandra (Schisandra chinensis) is a fruit used in Traditional Chinese Medicine as an adaptogen and hepatoprotective herb. Modern research has explored its role in supporting normal Phase I and Phase II liver enzyme activity, protecting liver cells from oxidative stress, and supporting liver resilience during periods of increased demand. It is one of the most widely used botanicals in liver support formulas alongside Milk Thistle.
Is this product suitable for vegans?
Yes. NOW Foods Liver Refresh uses hypromellose vegetable capsules and contains no animal-derived ingredients. It is also certified halal, gluten-free, and free from dairy, soy, eggs, nuts, and shellfish.
How long does one bottle last?
The 90-capsule bottle provides 30 servings at 3 capsules per day - a 1-month supply.
Who should avoid this product?
This product is for adults only. Those who are pregnant or nursing, taking prescription medication, or managing a medical condition should consult a healthcare professional before use. Those with a known allergy to plants of the Asteraceae family (which includes artichoke) should also consult a healthcare professional before use.