New Era Comb G combines calc fluor, calc phos, kali phos and nat mur. Calc fluor is the tissue salt most often associated with elasticity and firm tissue support, calc phos is commonly linked with rebuilding, kali phos is traditionally used for nerve-related discomfort and tiredness, and nat mur is often chosen where fluid balance and circulation seems part of the problem.
That ingredient mix explains why New Era Comb G is used for backache, lumbago and piles. It leans toward support for strained tissues and uncomfortable pressure rather than general joint wear. Biotin is added as a small nutrient extra for normal energy metabolism and normal mucous membranes.
Calc fluor is the ingredient that makes this blend especially relevant when support and tone are part of the buying decision. In tissue salt practice it is often used for stretched or less resilient tissues, which fits the way this formula is traditionally positioned.