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SAMe 400mg (Double Strength)

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Original Price $90.05
Current Price $81.00

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SAMe is a natural substance found throughout the body that is synthesized from the amino acid Methionine and is one of the most important methyl donors in the central nervous system. Methylation is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissues including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.


  • Supports enhanced mood and cognitive health
  • Essential for healthy metabolism of major brain transmitters, serotonin and norepinephrine
  • Helps promote joint comfort and mobility
  • Supports liver health and detoxification
  • Supports energy production
  • Enteric coated tablets for optimum stability and potency. Able to survive stomach acid and reach intestines for optimal absorption

Supports joint health and mobility
SAMe’s ‘active sulphur’ group supports collagen and proteoglycan production, essential components of connective tissue. These nutrients surround the joint and serve to act as a cushion in the cartilage enhancing mobility and movement and promoting joint comfort.
Supports mood and cognitive health
SAMe is essential for the metabolism of major brain neurotransmitters, such as dopamine, serotonin and norepinephrine. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.
Supports liver and intestines
The liver makes most of the body’s SAMe and relies on SAMe for its structural and functional integrity. SAMe enhances liver synthesis of glutathione an important antioxidant. The liver’s SAMe reserves are depleted by alcohol and toxins. Studies show SAMe may protect liver injury caused by a number of toxins.
Support for energy production
SAMe is required by the mitochondria, in the cells, to produce CoQ10, alpha lipoic acid and other nutrients crucial for energy production.


Adults: Take 1 tablet daily away from food, or as directed by a health care professional.
Do not chew or crush tablet. Swallow whole.


Each enteric coated tablet contains: S-Adenosyl Methionine 400 mg (from SAM-e tosylate disulfate). Other Ingredients: Microcrystalline cellulose, magnesium hydroxide, stearic acid, calcium chloride anhydrous, magnesium stearate, colloidal silica anhydroud, calcium oxide, magnesium silicate, natural food glaz, arginine base, glycerol, sodium alginate.

Keep out of reach of Children. Warning: Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.